Supplementary Data on FGFR1/YAP1 Signaling in Renal Fibrosis from Mouse and Human Models

A 2.1 MB DOCX file containing supplementary data for a study on renal fibrosis. The research, authored by Xin Jiang and last updated in April 2026, investigates the FGFR1/YAP1 signaling axis in endothelial cells using human kidney samples, a UUO mouse model, and in vitro HUVEC experiments. The study employs genetic, pharmacological, and biochemical techniques to propose a novel therapeutic target for chronic kidney disease.

Use Cases

• Validate computational models of endothelial-to-mesenchymal transition (EndMT) based on the described FGFR1-ERK-YAP1 cascade.
• Correlate gene expression patterns for FGFR1 and YAP1 with fibrotic progression based on the analysis of human and mouse samples.
• Benchmark therapeutic intervention strategies for renal fibrosis based on the pharmacological and genetic inhibition results described.
• Study the role of TGF-β in activating pro-fibrotic signaling pathways in endothelial cells based on the mechanistic findings.

Strengths

• Data is associated with a study employing multiple validation techniques, including human samples, mouse models, and in vitro cell work.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.
• Last update timestamp is precisely recorded as 2026-04 13 05:31:55.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The primary data format is a DOCX file, which may require extraction or conversion for computational analysis.
• The dataset's scale is small at 2.1 MB, potentially limiting the volume of raw data available.

Provenance

Source

figshare, author Xin Jiang.

Collection Method

Data generated from analysis of human fibrotic kidney samples, a unilateral ureteral obstruction (UUO) mouse model, and in vitro human umbilical vein endothelial cells (HUVECs).

Time Range

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Freshness

Last updated 2026-04-13 05:31:55.

Geography

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