Murine Study Meta-Analysis on Dihydromyricetin for Liver Disease

Fourteen controlled murine studies quantify the effects of the flavonoid dihydromyricetin on diet-induced liver disease. Dachuan Jin compiled this systematic review and meta-analysis, registered with PROSPERO and last updated in April 2026. The analysis pools data on outcomes like hepatic triglycerides, liver enzymes, and inflammatory markers from studies published up to December 2025.

Use Cases

• Compare standardized mean differences for hepatic triglyceride and total cholesterol levels between DHM-treated and control groups.
• Analyze the relationship between DHM dose, treatment duration, and improvements in liver enzymes (ALT, AST, ALP).
• Investigate pooled effects on antioxidant markers (SOD, CAT, GSH) and inflammatory cytokines (TNF-α, IL-6).
• Assess heterogeneity in outcomes like body weight, liver index, and serum lipid profiles (LDL, HDL) across included studies.
• Examine the reported increase in the pAMPK/AMPK signaling ratio as a potential mechanism of action.

Strengths

• Includes 14 controlled murine studies, providing a quantitative synthesis of preclinical evidence.
• Reports pooled standardized mean differences with 95% confidence intervals for over 10 distinct physiological outcomes.
• Follows PRISMA 2020 guidelines and was prospectively registered in the PROSPERO database (CRD420251119087).
• Searched 9 literature sources, including four major Chinese databases, from inception to December 2025.

Limitations

• Moderate to high statistical heterogeneity reported for several key outcomes, indicating variability between studies.
• Data is exclusively from murine models, limiting direct translation to human clinical contexts.
• The 2.4 MB file contains a single DOCX document, offering no structured, machine-readable data tables for direct analysis.

Provenance

Source

figshare, authored by Dachuan Jin.

Collection Method

Systematic review and meta-analysis of published controlled murine studies, following PRISMA 2020 guidelines.

Time Range

Literature search from database inception to December 15, 2025.

Freshness

Last updated on 2026-04-07; literature search current through December 15, 2025.