Rat Model Data on Ketogenic Diet Effects for Epilepsy and Cognition

A 15.7 KB supplementary document from a 2026 study on the microbiota-gut-brain axis. The research, authored by Yimin Chen, examines the effects of a 4-week ketogenic diet on cognitive deficits in rats with lithium-pilocarpine-induced status epilepticus. It includes results from Morris Water Maze tests and analyses of fecal short-chain fatty acids, serum amino acids, neurotransmitters, and gut microbiota composition.

Use Cases

• Analyzing the relationship between ketogenic diet and cognitive performance based on Morris Water Maze escape times and quadrant preference data.
• Investigating gut microbiota compositional shifts and their association with dietary interventions described in the results.
• Studying correlations between fecal short-chain fatty acid levels and serum neurotransmitter/amino acid alterations mentioned in the findings.
• Exploring potential biomarkers for cognitive improvement in epilepsy via the microbiota-gut-brain axis as discussed in the conclusions.

Strengths

• Includes statistically significant results (P < 0.05 to P < 0.0001) for multiple measured variables, such as escape times and levels of specific acids and neurotransmitters.
• Provides a detailed methodological description involving a controlled 4-week dietary intervention and multiple biological assays.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• The dataset is a 15.7 KB DOCX file, which is a very small supplementary document rather than a primary data repository.
• Column-level documentation and sample data are unavailable, requiring manual inspection of the file to understand data structure.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Experimental study on rats with induced status epilepticus, involving dietary control, behavioral testing (Morris Water Maze), and biochemical analysis.

Time Range

Study period not specified; document last updated in 2026.

Freshness

Last updated 2026-04 04:29:11; freshness should be verified.

Geography

Laboratory study; geographic location not specified.