Review of Gaps and Paths Forward in Cancer Pharmacology and Translational Research

A 148.2 KB review document authored by Elizabeth A. Hughes and last updated in April 2026. It discusses the high failure rate of oncology chemotherapies compared to other drug classes and the need to reframe preclinical drug efficacy evaluation. The text explores traditional pharmacodynamic and pharmacokinetic methods, as well as pharmacokinetic-pharmacodynamic models for tumor growth inhibition.

Use Cases

• Literature review on drug translation challenges based on the discussion of the 'valley of death' between bench research and clinical application.
• Analysis of pharmacokinetic-pharmacodynamic modeling approaches based on the description of their role in evaluating clinical translation potential.
• Studying tumor growth inhibition models based on the mention of pharmacokinetic-pharmacodynamic models in the review.

Strengths

• Document is under a CC-BY-4.0 license, allowing for broad reuse and adaptation.
• Author attribution (Elizabeth A. Hughes) is provided.

Limitations

• The 148.2 KB size suggests a limited scope, likely a single review article rather than a large dataset.
• Row count and column-level documentation are absent; the content is a text document, not structured data.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, authored by Elizabeth A. Hughes.

Collection Method

Likely a scholarly review article authored for publication.

Time Range

Publication or last update date is 2026-04-10.

Freshness

Last updated 2026-04-10 05:58:00; freshness should be verified.

Geography

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