Supplementary file 1_Genetic insights into unexplained infant jaundice: a study from north

Northern Guangdong, China. This dataset contains genetic screening results from a clinical study of 56 infants with unexplained jaundice, conducted at Yuebei People's Hospital from January 2022 to July 2024. The study, authored by Fangjian Gao and published under CC-BY-4.0, used targeted capture and high-throughput sequencing on 161 jaundice-related genes to identify pathogenic mutations.

Use Cases

• Identify high-frequency mutation sites for infant jaundice based on the reported UGT1A1, G6PD, and SLC10A1 gene variants.
• Analyze co-occurrence patterns of genetic disorders based on the described combinations like Gilbert syndrome with G6PD deficiency.
• Assess the diagnostic yield of targeted gene panels for unexplained jaundice based on the 51.8% positive result rate.
• Study population-specific genetic factors for jaundice based on the cohort from northern Guangdong, China.

Strengths

• Includes specific, quantified results: 56 infants, 29 positive cases (51.8%), and frequencies for six identified diseases.
• Identifies concrete high-frequency mutation sites in the UGT1A1, G6PD, and SLC10A1 genes.
• Has a clear temporal scope: data collected from January 2022 to July 2024.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (70.8 KB), indicating limited scope and sample size.

Provenance

Source

Yuebei People's Hospital, neonatology and pediatrics departments.

Collection Method

Targeted capture and high-throughput sequencing of exon regions from 161 jaundice-related genes.

Time Range

January 2022 to July 2024

Freshness

Last updated 2026-04-13 05:36:00; freshness should be verified.

Geography

Northern Guangdong, China