Postmortem Brain GWAS Data on Schizophrenia and Neurodevelopmental Disorder Polygenic Risk

Genome-wide association study data from the postmortem brains of 24 patients with schizophrenia and 48 controls. The dataset includes calculated polygenic risk scores for ADHD and autism spectrum disorder, and for 19 patients, it contains antemortem clinical information on symptom severity and antipsychotic responsiveness. The data was authored by Kazusa Miyahara and last updated on 2026-04-27.

Use Cases

• Correlating polygenic risk scores for ADHD and ASD with antipsychotic responsiveness scores in schizophrenia based on the described clinical metrics.
• Identifying differentially expressed genes in the prefrontal cortex based on high vs. low ADHD-PRS subgroups mentioned in the description.
• Analyzing pathway enrichment for neuronal system and mitochondrial function based on the 1,773 DEGs identified in the study.
• Investigating the role of specific genes like CHRNB2 in neuropsychiatric disorders using the gene expression data.

Strengths

• Includes genome-wide association study data from a specific cohort of 24 schizophrenia patients and 48 controls.
• Contains calculated polygenic risk scores for two neurodevelopmental disorders (ADHD and ASD) derived from public GWAS data.
• Links genetic data to clinical phenotypes for 19 patients, including antipsychotic responsiveness scores and symptom severity.

Limitations

• The sample size is limited to 24 patients and 48 controls, as noted in the study discussion.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Kazusa Miyahara

Collection Method

Data obtained from postmortem brain genome-wide association studies and linked to clinical records.

Freshness

Last updated 2026-04-27 05:18:06; freshness should be verified.