Supplementary file 1_Genomic analysis reveals multi-level resistance network linking oxida

A study of 282 Klebsiella pneumoniae strains from the United Arab Emirates tested for susceptibility to cefiderocol and other antibiotics. Whole-genome sequencing and bioinformatic analysis of 96 representative strains examined 51 genes across six functional categories, including oxidative stress pathways and iron regulation. The data was authored by Lana Daoud and last updated in May 2026.

Use Cases

• Identify genetic mutations associated with cefiderocol resistance based on the analysis of oxidative stress and iron regulation pathways.
• Study the co-occurrence of resistance mechanisms in high-risk clones like ST14 and ST147.
• Analyze network interactions between iron uptake, efflux pump, and DNA repair gene mutations.
• Investigate the correlation between OxyR regulon mutations and minimum inhibitory concentrations (MICs).

Strengths

• Includes phenotypic susceptibility data for 282 bacterial isolates.
• Provides whole-genome sequencing data for 96 representative strains.
• Analyzes 51 specific genes across six functional categories.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 88.4 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Whole-genome sequencing and bioinformatic analysis of clinical isolates.

Freshness

Last updated 2026-05-15 05:27:53; freshness should be verified.

Geography

United Arab Emirates