Canine Lymphoma Study: Urinary VOC Metabolites and Genotoxicity in Golden Retrievers

A 2026 study by Ashleigh N. Tindle investigates volatile organic compound (VOC) exposure in dogs with lymphoma. The dataset likely contains urinary metabolite measurements for benzene, xylene, and 1,3-butadiene from 60 golden retrievers (30 cases, 30 controls) at two time points: diagnosis and one year prior. It also includes in vitro genotoxicity data for benzene and xylene on canine blood cells.

Use Cases

• Analyze associations between urinary VOC metabolites and canine lymphoma status based on case-control measurements.
• Model reverse dosimetry to estimate blood concentrations from urinary metabolite data mentioned in the description.
• Investigate the relationship between secondhand smoke exposure (via cotinine) and VOC levels in dogs.
• Benchmark in vitro genotoxicity thresholds for benzene and xylene against estimated in vivo exposures in dogs.

Strengths

• Data from 60 golden retrievers provides a matched case-control cohort.
• Measurements taken at two time points (diagnosis and one year prior) allow for temporal analysis.
• Includes both in vivo biomarker data and in vitro experimental genotoxicity results.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count and specific column definitions are unknown, requiring inspection after download.
• The dataset is small (577.2 KB), indicating limited scope and sample size.
• Data is specific to one breed (golden retrievers), which may limit generalizability.

Provenance

Source

figshare, authored by Ashleigh N. Tindle.

Collection Method

Experimental study measuring urinary VOC metabolites and conducting in vitro genotoxicity assays.

Time Range

Study timeframe not explicitly stated; data includes measurements at diagnosis and one year prior.

Freshness

Last updated 2026-04-13 04:31:19.

Geography

Geographic coverage is not specified in the provided metadata.