Global Prevalence of Fluoroquinolone Resistance in E. coli from UTIs

A systematic review and meta-analysis of 36 studies published through December 2025, aggregating data on fluoroquinolone-resistant Escherichia coli isolated from urinary tract infections. The analysis, conducted by Hua Zhou, reports an overall pooled resistance prevalence of 31.09% with significant variation by specific agent and region.

Use Cases

• Estimating regional resistance rates for empirical therapy guidance based on the reported pooled prevalence and subgroup analyses.
• Analyzing trends in resistance to specific fluoroquinolone agents like ciprofloxacin and levofloxacin based on the reported agent-specific prevalence estimates.
• Investigating the relationship between study sample size and reported resistance rates based on the meta-regression results mentioned in the description.
• Identifying geographic regions with high resistance burdens for targeted surveillance based on the findings highlighting China, Iran, and Bangladesh.

Strengths

• Analysis is based on 36 studies identified from a systematic review of 9,033 records.
• Reports specific pooled prevalence estimates with 95% confidence intervals for overall resistance and for three specific agents (ciprofloxacin, levofloxacin, pefloxacin).
• Followed PRISMA guidelines and assessed study quality using the modified Newcastle-Ottawa Scale.

Limitations

• The primary data file is a 2.4 MB DOCX document; the underlying tabular data for meta-analysis may not be machine-readable.
• Row count and column-level documentation for any underlying data are unknown.
• The geographic coverage is inferred from the results; the specific source data for each region is not detailed.

Provenance

Source

figshare, authored by Hua Zhou.

Collection Method

Systematic review and meta-analysis of observational studies from PubMed, Embase, and Web of Science.

Time Range

Studies published through December 2025.

Freshness

Last updated 2026-05-20 05:38:23.

Geography

Global, with specific mentions of China, Iran, and Bangladesh.