Gut Microbiota and Mental Health in IBD: A Systematic Review of 10 Studies

Ten studies, including six prospective cohorts and four randomized trials, were systematically reviewed to evaluate links between gut microbiota and anxiety/depression in inflammatory bowel disease patients. The review synthesizes evidence from 1,040 patients, covering records from database inception to October 17, 2025. It was authored by Tao Zhang and published on figshare under a CC-BY-4.0 license.

Use Cases

• Conducting meta-analyses on the association between microbial alpha-diversity and psychological symptoms based on the review's findings.
• Designing clinical trials for microbiota-targeted interventions like probiotics or fecal microbiota transplantation based on the synthesized RCT evidence.
• Developing hypotheses for longitudinal studies on the bidirectional relationship between pro-inflammatory taxa and depression in IBD remission.
• Informing personalized medicine approaches by integrating psychological and microbial profiling data as suggested in the review.

Strengths

• Systematic methodology following PRISMA guidelines and registered with PROSPERO (CRD420251166542).
• Includes a synthesis of 10 studies with a total of 1,040 patient records.
• Explicitly reports the search strategy across six major databases up to a specific date (October 17, 2025).

Limitations

• The underlying data file is a 39.8 KB DOCX document, which is a small supplementary file rather than a primary dataset.
• Row and column-level data are unavailable; the content is a descriptive synthesis without raw tabular data.
• Findings are described as heterogeneous, indicating inconsistencies across the included studies.

Provenance

Source

figshare

Collection Method

Systematic review and descriptive synthesis of randomized controlled trials and prospective cohort studies.

Time Range

Records from database inception to October 17, 2025.

Freshness

Last updated 2026-06-02 05:31:24.