Gut Microbiota and Bile Acid Profiles in IBD Patients

104 participants, including 31 ulcerative colitis patients, 41 Crohn's disease patients, and 32 healthy controls, were recruited for this study. Zhejiong Wang authored this research, which profiles gut microbiota via 16S rDNA sequencing and serum bile acids via LC-MS/MS. The dataset was last updated in April 2026.

Use Cases

• Classify ulcerative colitis vs. Crohn's disease vs. healthy control status using genus-level abundances like Escherichia-Shigella and Ruminococcus_gnavus_group.
• Model correlations between depleted secondary bile acid levels (e.g., LCA, DCA, GDCA) and abundances of specific bacterial genera such as Lachnospiraceae.
• Identify biomarkers for disease severity by analyzing depletion patterns of SCFA-producing genera like Coprococcus, Romboutsia, and Butyricicoccus.
• Assess alpha and beta diversity metrics to quantify gut microbiota dysbiosis in patient groups compared to controls.

Strengths

• Data from 104 clinically characterized participants provides a matched cohort for comparison.
• Includes two complementary data modalities: 16S rDNA sequencing for microbiota and LC-MS/MS quantification for 5+ specific bile acids.
• Statistical results include FDR-corrected differential abundance tests and Spearman correlation analyses between genera and bile acids.

Limitations

• Small sample size of 104 total participants limits statistical power for subgroup analyses.
• Geographic bias: all participants were recruited from a single hospital in China, limiting generalizability.
• The 395.7 KB file size suggests the data is likely summary results, not the raw sequencing or mass spectrometry data.

Provenance

Source

figshare, authored by Zhejiong Wang.

Collection Method

Clinical recruitment, 16S rDNA sequencing of stool samples, and LC-MS/MS analysis of serum.

Time Range

null

Freshness

Last updated in April 2026, indicating recent availability.

Geography

Participants recruited from The First Affiliated Hospital of Zhejiang Chinese Medical University, China.