Gut Microbiome of 58 Uruguayan Children with Autism Spectrum Disorder and Sibling Controls

Supplementary file 1 from a study by Florencia Peñalba, last updated March 2026. The dataset likely contains gut bacterial composition data for 29 children with Autism Spectrum Disorder (ASD) and 29 neurotypical sibling controls, all aged 4-10 and cohabiting in Uruguay. Data was generated using full-length 16S rRNA gene sequencing with Oxford Nanopore R10.4.1 chemistry.

Use Cases

• Compare gut microbial composition between ASD and neurotypical groups based on sibling-matched cohort design.
• Analyze associations between specific bacterial taxa and gastrointestinal symptoms mentioned in the description.
• Investigate the influence of pharmacological treatments like antipsychotics, melatonin, and methylphenidate on microbiome abundance.
• Study the gut microbiota in a specific geographic and demographic context based on the Uruguayan cohort.

Strengths

• Sibling-matched cohort design with 29 ASD-NT pairs to minimize environmental confounders.
• Uses high-resolution full-length 16S rRNA gene sequencing with Oxford Nanopore R10.4.1 chemistry.
• Includes metadata on gastrointestinal symptoms and pharmacological treatments for association analysis.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is relatively small (3.2 MB), potentially limiting statistical power for complex analyses.
• Data may reflect geographic and demographic bias inherent to the Uruguayan cohort.

Provenance

Source

Florencia Peñalba via figshare.

Collection Method

Cross-sectional study using full-length 16S rRNA gene sequencing on fecal samples.

Time Range

null

Freshness

Last updated 2026-03 24 16:03:18.

Geography

Uruguay.