HLA Allele-Specific TCR Vβ Gene Usage Profiles from Population-Scale Repertoires

A 6.1 MB supplementary file by Leonardo V. Castorina, last updated in May 2026, provides allele-specific T-cell receptor Vβ gene usage profiles. The data was constructed from population-scale TCRβ repertoires linked to donor HLA genotypes inferred using validated imputation models. It supports analysis of germline-driven constraints on TCR–HLA compatibility.

Use Cases

• Deriving HLA-Vβ preference vectors based on normalized, allele-specific TCR Vβ gene usage profiles.
• Analyzing similarities in HLA amino-acid sequences to predict similarities in Vβ preferences and peptide-binding motifs.
• Disentangling HLA positions associated with Vβ engagement from those associated with peptide motifs through residue-level analysis.
• Benchmarking TCR-pHLA specificity prediction methods by accounting for HLA-specific TCR Vβ biases.

Strengths

• Data is derived from population-scale TCRβ repertoires linked to donor HLA genotypes.
• Includes a residue-level analysis distinguishing TCR-facing helices from peptide-binding pockets.
• Uses validated imputation models for HLA genotype inference.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 6.1 MB PDF, which may require extraction of underlying tabular data.

Provenance

Source

figshare

Collection Method

Constructed from population-scale TCRβ repertoires linked to imputed donor HLA genotypes.

Freshness

Last updated 2026-05-29 08:22:42; freshness should be verified.