Honeybee Venom Antiviral Activity: A Systematic Review and Meta-Analysis

Sirwan Sleman's systematic review and meta-analysis synthesizes preclinical and clinical evidence on the antiviral efficacy and safety of honeybee venom. The work, updated in March 2026, includes quantitative synthesis from 32 identified articles. It provides evidence for antiviral activity against viruses like influenza, herpes simplex, HIV, hepatitis, and coronaviruses.

Use Cases

• Summarizing evidence on antiviral mechanisms based on described pathways like viral replication disruption and immunomodulation.
• Assessing treatment safety profiles based on reported adverse effects like cytotoxicity and allergic responses.
• Identifying research gaps for future clinical trials based on the noted limitations of existing human studies.
• Evaluating the potential of formulation improvements mentioned, such as nanocarriers or combination therapies.

Strengths

• Includes a quantitative synthesis of 32 identified research articles.
• Meta-analysis provides evidence for broad-spectrum antiviral activity against multiple virus families.
• Reports specific safety data, including a rare anaphylaxis incidence rate of less than 0.1%.

Limitations

• The underlying data file is a 42.7 KB DOCX document, indicating a limited scope of directly accessible structured data.
• Row count and column-level documentation are absent; data structure must be inferred from the text.
• The description notes high heterogeneity and limitations in the majority of the included studies.

Provenance

Source

Sirwan Sleman via figshare

Collection Method

Systematic review and meta-analysis of studies from electronic databases up to October 2025.

Time Range

Studies from database inception up to October 2025.

Freshness

Last updated 2026-03-18 07:35:30