Influenza B Vaccine Antibody Response Study in 15 Participants

15 vaccinated participants were profiled over four consecutive influenza seasons for influenza B virus hemagglutinin-specific B-cell responses. The study isolated monoclonal antibodies, including mAb #46, which showed broad binding and functional activity against historical and recent IBV strains spanning Victoria and Yamagata lineages.

Use Cases

• Analyze the breadth and magnitude of antibody responses across age groups (young adults, middle-aged, elderly) to a panel of IBV vaccine strains.
• Study the binding profile of isolated monoclonal antibodies, such as mAb #46, against computationally optimized broadly reactive antigen (COBRA) HAs.
• Investigate the structural characterization of antibody-HA complexes, like the mAb #46–HA complex, via cryo-electron microscopy single-particle analysis.

Strengths

• Longitudinal data from 15 participants tracked over four consecutive influenza seasons.
• Includes structural characterization of a monoclonal antibody-HA complex via cryo-electron microscopy.
• Monoclonal antibodies were tested against a panel of historical and recent IBV strains from both Victoria and Yamagata lineages.

Limitations

• Small cohort size of 15 participants limits statistical power and generalizability.
• Data is presented in a DOCX document, requiring manual extraction for quantitative analysis.
• Sample data and structured columns are unavailable, hindering direct computational use.

Provenance

Source

figshare, author Yailin Campos Mota.

Collection Method

Longitudinal profiling of B-cell responses following influenza vaccination; monoclonal antibodies isolated from plasmablasts.

Time Range

Four consecutive influenza seasons.

Freshness

Last updated March 2026.

Geography

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