Huoxue Jiegu Compound Capsule Mechanisms for Tibial Fracture Healing

A research document details an integrative study combining network pharmacology, molecular docking, and in vivo experiments to investigate the mechanisms of a traditional Chinese medicine capsule. The analysis identified 209 candidate bioactive compounds and 185 overlapping targets, with key hub targets including AKT1, STAT3, IL6, BCL2, EGFR, and JUN. The study was authored by Weisong Lu and last updated in May 2026.

Use Cases

• Validate network pharmacology predictions based on the 209 candidate compounds and 185 overlapping targets identified.
• Study angiogenesis-related signaling pathways like HIF-1 and PI3K-Akt based on the functional enrichment analysis results.
• Investigate multi-component, multi-target mechanisms in traditional medicine based on the molecular docking and dynamics simulations described.

Strengths

• The study integrates multiple methodologies, including network pharmacology, molecular docking, 100-ns molecular dynamics simulations, and in vivo validation.
• Specific quantitative results are reported, including 209 candidate compounds and 185 overlapping targets.
• The document is licensed under CC-BY-4.0, allowing for open sharing and reuse.

Limitations

• The dataset is a single 18.2 KB DOCX file, indicating a very limited scope and likely containing only textual results, not raw data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Integrative strategy combining computational and experimental biology techniques.

Freshness

Last updated 2026-05-11 05:28:59; freshness should be verified.