Supplementary Data for Hyperoxia-Induced BPD via Noggin-BMP4 Signaling

A 5.5 MB supplementary document uploaded to figshare by Jiaxin Zhang on April 20, 2026, under a CC-BY-4.0 license. The document likely contains supporting data and analysis for a study investigating how hyperoxia upregulates Noggin to antagonize BMP4 signaling, activating p53/p21-mediated cellular senescence and contributing to bronchopulmonary dysplasia in preterm infants.

Use Cases

• Validate bioinformatics findings on the Noggin-BMP4 axis based on the described transcriptomic and WGCNA analysis.
• Replicate in vitro hyperoxia exposure experiments on HPMECs based on the reported mRNA and protein expression changes.
• Benchmark results from the neonatal rat hyperoxia-induced BPD model based on the described alveolar simplification and gene expression data at day 14.

Strengths

• Includes specific quantitative results, such as a 2.5-fold increase in Noggin mRNA and a reduction of BMP4 to 30% of controls in animal models.
• Integrates multiple analysis methods mentioned in the description, including bioinformatics, WGCNA, and both in vitro and in vivo validation.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data format is DOCX, which may require extraction or conversion for computational analysis.

Provenance

Source

figshare

Collection Method

Likely contains experimental and bioinformatics data generated for the associated research study.

Time Range

Temporal coverage of the experimental data is not specified.

Freshness

Last updated 2026-04-20 04:13:16; freshness should be verified.

Geography

Spatial coverage is not specified.