Hyposalivation and Salivary Gland Histopathology in Graft-Versus-Host Disease

Supplementary file 1_Hyposalivation and salivary gland histopathology in graft-versus-host disease.docx is a research dataset by Victor Tollemar, last updated May 8, 2026. It contains retrospective clinical data from 791 patient records, analyzing 63 unstimulated and 123 stimulated saliva measurements and 57 minor salivary gland biopsies. The study explores associations between hyposalivation, gland histopathology, and GVHD progression following allogeneic hematopoietic cell transplantation.

Use Cases

• Correlating salivary flow measurements with transplant conditioning regimens based on the analysis of unstimulated and stimulated saliva.
• Analyzing histopathological severity scores between minor salivary gland and oral mucosal tissue based on NIH criteria grading.
• Investigating immune cell infiltration (CD4, CD8, CD68, CD1a) in salivary glands at different GVHD phases based on immunohistochemical staining results.
• Modeling the progression of oral chronic GVHD based on temporal correlations between pathology scores and immune markers.

Strengths

• Includes data from 791 screened patient records, providing a substantial clinical cohort.
• Analyzes 63 unstimulated and 123 stimulated saliva measurements, offering multiple physiological metrics.
• Contains histopathological grading for 57 biopsies and immunohistochemical staining for 40 biopsies, enabling tissue-level analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect temporal or institutional bias inherent to the single retrospective study.

Provenance

Source

Victor Tollemar via figshare.

Collection Method

Retrospective screening of patient records and analysis of saliva measurements and biopsies.

Time Range

Not specified in the provided metadata.

Freshness

Last updated 2026-05-08 05:53:13; freshness should be verified.

Geography

Not specified in the provided metadata.