MTMR2 Gene Expression and Lipid Parameters in Acute Myeloid Leukemia Patients

A study by Chenchen Liu, last updated May 2026, identifies the gene MTMR2 as a candidate biomarker for Acute Myeloid Leukemia (AML). The analysis integrates expression profiles from GSE114868 and GSE9476 datasets and validates findings with RT-qPCR on an expanded clinical cohort. The dataset likely contains gene expression levels and associated clinical lipid parameters like ApoA1, LDL-C, and TG.

Use Cases

• Diagnostic biomarker validation based on MTMR2 expression levels mentioned in the description
• Survival analysis based on the association between high MTMR2 expression and poorer overall survival
• Immune infiltration analysis based on inferred immune-cell patterns associated with MTMR2 expression
• Correlation analysis between gene expression and lipid-related clinical parameters like ApoA1, LDL-C, and TG

Strengths

• Analysis integrates multiple public datasets (GSE114868 and GSE9476) and an expanded clinical cohort for validation
• Candidate biomarker MTMR2 was identified using multiple machine-learning methods (LASSO, random forest, SVM-RFE)
• Includes exploratory clinical data on lipid parameters (ApoA1, LDL-C, TG) from AML patients and healthy controls

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is small (169.8 KB), indicating limited scope, likely containing summary or supplementary results rather than raw data

Provenance

Source

figshare, author Chenchen Liu

Collection Method

Analysis of public gene expression datasets (GSE114868, GSE9476) and validation via RT-qPCR on a clinical cohort

Freshness

Last updated 2026-05-29 04:48:59; freshness should be verified