Supplementary file 1_Immune biomarker landscape and fusion partner–phenotype associations

An integrated clinicopathologic dataset of 229 thoracic and head-and-neck NUT carcinoma cases with definitive fusion annotations, compiled from 109 studies. The data includes lineage, fusion partner, and immune biomarker status such as PD-L1, MSI, and TMB. It was created by Shuang Xiang and last updated in May 2026.

Use Cases

• Associating fusion partner genotypes with tumor phenotypes based on lineage and anatomic strata.
• Analyzing the prevalence of immune biomarkers like PD-L1 negativity across different tumor subsets.
• Investigating correlations between specific fusion partners and immune biomarker expression patterns.

Strengths

• Dataset includes 229 case-level records with definitive fusion annotations.
• Data is harmonized from 109 studies, providing a multi-source perspective.
• Analysis includes an independent validation cohort of 59 patients.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the full dataset is unknown, which may limit suitability assessment.
• Data may reflect publication bias inherent to literature-based analysis.

Provenance

Source

Integrated literature-based analysis from the Web of Science Core Collection and an independent institutional cohort.

Collection Method

Case-level data harmonized from English-language publications indexed from 1991 to 2025.

Time Range

Publications from 1991 to 2025.

Freshness

Last updated 2026-05-28 05:58:20