Immune Interaction Between Aspergillus Fumigatus and Non-Tuberculous Mycobacteria

A study investigating microbial cross-modulation between Aspergillus fumigatus and non-tuberculous mycobacteria (NTM). The research includes in vitro assays quantifying biofilm formation and macrophage phagocytosis, as well as in vivo mouse model data on fungal clearance. The dataset, authored by Hotaka Namie and shared under CC-BY-4.0, was last updated on 2026-05-04.

Use Cases

• Modeling host-pathogen interactions based on described macrophage phagocytosis assays.
• Investigating microbial co-colonization mechanisms based on the described cross-modulation of immune function.
• Developing therapeutic strategies for chronic pulmonary aspergillosis based on the identified impairment of fungal clearance.

Strengths

• The description provides specific quantitative results, such as a 40% decrease in phagocytosis rate and a halving of Dectin-1 gene expression.
• The study design includes multiple experimental approaches: in vitro biofilm assays, macrophage infection models, and an in vivo mouse model.

Limitations

• The dataset is a single 884.7 KB DOCX file, suggesting limited scope and scale.
• Row count and column-level documentation are absent; data structure must be inferred after download.
• The description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental research involving laboratory assays and animal models as described.

Freshness

Last updated 2026-05-04 05:34:06; freshness should be verified.