Impact of DPP1 and NSP Inhibition on Neutrophil Responses

A research document analyzes the effects of dipeptidyl peptidase-1 (DPP1) and neutrophil serine protease (NSP) inhibition on neutrophil functions. The study uses brensocatib inhibitor and knockout mice models, authored by Dedong Li and uploaded to figshare in April 2026. It investigates granulocytic differentiation, migration, phagocytosis, reactive oxygen species production, bacterial killing, and neutrophil extracellular trap formation.

Use Cases

• Evaluate the selectivity of DPP1 inhibitors based on functional assays described.
• Compare neutrophil responses between mouse knockout models and human cells as outlined.
• Investigate the role of neutrophil serine proteases in NET formation as discussed.
• Assess the impact of enzyme ablation on core neutrophil functions like phagocytosis and migration.

Strengths

• Includes data from both mouse models and human neutrophils.
• Focuses on a specific therapeutic target (brensocatib) with dose-dependent results.
• License is CC-BY-4.0, allowing open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is presented in a DOCX file (1.6 MB), which may require extraction for analysis.

Provenance

Source

figshare

Collection Method

Experimental research using inhibitor treatment and genetic knockout models.

Freshness

Last updated 2026-04-24 05:36:17; freshness should be verified.