Risk Factors for Rapidly Progressive ILD in Anti-MDA5 Dermatomyositis: Meta-Analysis

15 studies were included in a meta-analysis investigating factors for rapidly progressive interstitial lung disease in patients with anti-MDA5-positive dermatomyositis. The analysis identified 13 risk factors and 2 protective factors, with odds ratios ranging from 1.03 to 5.05. The dataset was created by Haixia Li and last updated on April 10, 2026.

Use Cases

• Predicting RP-ILD risk based on demographic factors like male sex and advanced age
• Identifying RP-ILD risk based on clinical markers like elevated CRP, ferritin, and LDH
• Analyzing RP-ILD risk based on immunological markers like anti-Ro52 antibody positivity
• Evaluating RP-ILD risk based on hematological indicators like neutrophil-to-lymphocyte ratio and lymphopenia

Strengths

• All 15 included studies were assessed as high quality with an average Newcastle-Ottawa Scale score of 7.9
• The meta-analysis provides specific odds ratios and confidence intervals for 15 distinct factors
• The systematic search covered five major databases with a defined search period

Limitations

• The dataset is a 15.1 MB DOCX file; the underlying tabular data structure and column definitions are not explicitly described
• The row count for the aggregated meta-analysis data is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus.

Time Range

Search period extended to January 1, 2026.

Freshness

Last updated 2026-04-10 06:02:35