Supplementary file 1_Integrated metabolomics and computational analysis suggest that a San

A supplementary document from a study investigating the therapeutic mechanisms of a Sanghuangporus vaninii-based functional food formulation (FSV) for type 2 diabetes mellitus (T2DM). The research used UPLC-QTOF/MS chemical profiling, network pharmacology, a T2DM mouse model with a 4-week intervention, hepatic metabolomics, and molecular docking. The 23.9 MB DOCX file was authored by Zifeng Huang and last updated on 2026-05-08.

Use Cases

• Validate computational docking predictions for metabolite-target interactions based on the identified morphine-3-glucuronide (M3G) metabolite.
• Analyze the chemical profiling results to identify core bioactive flavonoids like apigenin and tangeritin for further study.
• Compare metabolic pathway modulation, such as the glucagon signaling pathway, between intervention and control groups in the described mouse model.
• Replicate network pharmacology workflows to identify potential bioactive constituents from complex natural product mixtures.

Strengths

• Integrated multi-omics approach combining chemical profiling (766 compounds identified), in vivo models, and computational analysis.
• Study design includes a positive control (metformin) and a defined mouse model with 10 subjects per group over a 4-week intervention.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• The primary data file is a DOCX document; underlying raw metabolomics or numerical data may not be directly accessible.
• Description metadata is limited; actual data quality and structure require manual inspection after download.
• The computational findings, such as M3G's interaction with PIK3CA/EGFR, are noted as requiring experimental validation.

Provenance

Source

figshare

Collection Method

Generated from an experimental study using UPLC-QTOF/MS, mouse models, and computational docking.

Time Range

Study period not specified; document last updated in 2026.

Freshness

Last updated 2026-05-08 05:51:11; freshness should be verified.

Geography

Not specified.