Supplementary file 1_Integrative genomic and multi-omics analyses identify oxidative stres

Supplementary data from a multi-omics study investigating oxidative stress-related pathways in tinnitus. The dataset, authored by Jingjie Han and last updated in April 2026, integrates GWAS meta-analysis with DNA methylation, gene expression, and protein QTLs for 1,844 oxidative stress-related genes. It includes results from prioritization, validation in independent cohorts, and molecular docking analyses.

Use Cases

• Prioritizing candidate genes for tinnitus based on integrated multi-omics evidence.
• Investigating oxidative stress-mediated immune and metabolic pathways in auditory disorders.
• Identifying druggable targets and repurposable drugs like fenretinide via molecular docking.
• Validating genetic findings in independent cohorts and brain-specific datasets.

Strengths

• Integrates data from GWAS meta-analysis, DNA methylation, gene expression, and protein QTLs.
• Focuses on a specific set of 1,844 oxidative stress-related genes.
• Includes experimental validation of ACADVL mRNA and protein levels in human plasma.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary file is a 2.1 MB DOCX document, which may require extraction of structured data.

Provenance

Source

figshare

Collection Method

Integrated genomic and multi-omics analyses, including GWAS, QTL mapping, and experimental validation.

Time Range

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Freshness

Last updated 2026-04-28 04:24:50; freshness should be verified.

Geography

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