SNRPA Overexpression RNA-seq and iRIP-seq Analysis in HepG2 Cells

498 differentially expressed genes and 2,316 alternative splicing events were identified in HepG2 cells overexpressing the RNA-binding protein SNRPA. The dataset, authored by Qingyao Chang and last updated in May 2026, integrates RNA-seq and iRIP-seq data to link SNRPA binding to transcriptomic and splicing alterations relevant to liver cancer.

Use Cases

• Identify SNRPA-regulated transcripts and alternative splicing events based on RNA-seq data.
• Map SNRPA RNA interactomes based on iRIP-seq binding data.
• Analyze enrichment of SNRPA-bound genes in RNA processing and cell division pathways based on functional annotation results.
• Investigate the regulatory network of RNA-binding proteins like PCBP2 and HNRNPH1 in hepatocellular carcinoma based on their dysregulation by SNRPA.

Strengths

• Integrates two complementary sequencing assays: RNA-seq and iRIP-seq.
• Quantifies specific findings: 498 differentially expressed genes and 2,316 alternative splicing events.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is derived from a single cell line (HepG2), which may limit generalizability.

Provenance

Source

figshare

Collection Method

Generated from SNRPA-overexpressing HepG2 cells via RNA-seq and iRIP-seq, with integrative bioinformatics analysis.

Freshness

Last updated 2026-05-01 04:17:46; freshness should be verified.