Mouse Hippocampal Mitochondrial and Neuronal Data After Whole-Brain Radiation and Fasting

A 761.5 KB document details a study on intermittent fasting's effects on radiation-induced brain injury in mice. Author Yaqi Li published the supplementary file on figshare under a CC-BY-4.0 license, last updated May 14, 2026. The research evaluated mitochondrial swelling, ATP concentrations, neurogenesis, and cognitive behavior in C57BL/6J mice at 6 hours and 6 weeks post-irradiation.

Use Cases

• Analyzing the relationship between intermittent fasting and mitochondrial ultrastructure changes based on electron microscopy data.
• Modeling the time-dependent effects of dietary intervention on neurogenesis based on DCX+ neuron counts and morphology.
• Investigating behavioral outcomes of neuroprotective strategies based on elevated plus-maze test results.
• Correlating ATP concentration levels with neuronal structural integrity metrics like branch points and neuron length.

Strengths

• The study design includes specific, timed measurements at 6 hours and 6 weeks post-intervention.
• Results are supported by statistical p-values for multiple outcome measures, including mitochondrial swelling and neuron morphology.
• The document is openly licensed under CC-BY-4.0 for reuse.

Limitations

• The dataset is a 761.5 KB DOCX file containing textual results, not a structured data table; column-level documentation is absent.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.
• The data is derived from a specific mouse model (C57BL/6J), which may limit generalizability.

Provenance

Source

Yaqi Li via figshare.

Collection Method

Experimental study using a whole-brain radiotherapy mouse model with intermittent fasting intervention.

Time Range

Measurements taken at 6 hours and 6 weeks post-irradiation.

Freshness

Last updated 2026-05-14 05:43:23; freshness should be verified.