Polygala Total Saponins: Mouse Intestinal Toxicity Data via Toxicological Evidence Chain

A 29.9 MB supplementary document details a toxicological study on Polygala total saponins (PTS) in mice. Author Yulu Liang published the work on figshare in May 2026 under a CC-BY-4.0 license. The study investigates intestinal damage mechanisms, analyzing histopathology, serum biochemistry, tight junction expression, fecal SCFAs, 16S rRNA sequencing, and multi-omics data.

Use Cases

• Modeling intestinal toxicity mechanisms based on described multi-omics and histopathological evidence.
• Analyzing correlations between specific gut microbiota (e.g., Lachnospiraceae) and toxic outcomes like weight loss.
• Investigating the role of arachidonic acid metabolism in drug-induced intestinal inflammation.
• Benchmarking or refining the Toxicological Evidence Chain (TEC) concept with experimental data.

Strengths

• Study design includes five key experiments providing multiple lines of toxicological evidence.
• Data integrates multiple analysis types: histopathology, serum biochemistry, 16S rRNA sequencing, metabolomics, and transcriptomics.
• Released under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The primary data file is a 29.9 MB DOCX document; underlying raw datasets (e.g., sequencing reads, metabolomics tables) are not directly accessible in a structured, machine-readable format.
• Row and column counts for any underlying data tables are unknown, limiting suitability assessment for computational analysis.
• The dataset is focused on a single compound (PTS) in a specific mouse model (male ICR mice), which may limit generalizability.

Provenance

Source

figshare

Collection Method

Experimental study involving administration of Polygala total saponins to mice, followed by sample collection and multi-modal analysis.

Freshness

Last updated 2026-05-20 05:38:26.