Mouse Study on Intracerebroventricular Diphtheria Toxin Off-Target Effects

A 10-day study by Jessica Irving, last updated in April 2026, examines off-target toxicity from intracerebroventricular diphtheria toxin in wild-type and CD11b-DTR mice. The dataset includes outcomes on survival, motor and cognitive behavior, myeloid cell changes, and neuropathology. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Assess dose-dependent mortality and behavioral impairments in mice based on the described rotarod and Y-maze testing.
• Analyze region-specific myeloid cell depletion and activation in the brain based on the described midbrain and hippocampal findings.
• Investigate focal CNS pathologies like ventriculitis and spongiotic changes described in the subset of affected animals.

Strengths

• Includes data from a 10-day experimental period with multiple assessment endpoints.
• Explicitly compares outcomes between wild-type and transgenic CD11b-DTR mice.
• Contains behavioral, cellular, and neuropathological data as described in the summary.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 1.5 MB DOCX, which may not be in a standard analysis-ready format.

Provenance

Source

figshare

Collection Method

Experimental study involving bilateral intracerebroventricular infusions of diphtheria toxin or vehicle in mice.

Time Range

The experimental period covered 10 days.

Freshness

Last updated 2026-04-23 05:26:39; freshness should be verified.