Acacia Nilotica Pod Extract Study on Hypercholesterolemia in Rats

Khurram Afzal authored a research document investigating Acacia nilotica pod extracts. The study measured antioxidant activity, lipid profiles, cardiac enzymes, and oxidative stress markers in male albino Wistar rats with diet-induced hypercholesterolemia. The document includes in silico analyses of β-sitosterol's potential to inhibit cholesterol biosynthesis.

Use Cases

• Analyzing antioxidant efficacy based on total phenolic content, FRAP, and DPPH inhibition measurements.
• Evaluating antihyperlipidemic effects based on serum cholesterol, LDL, HDL, and atherogenic index data.
• Investigating hepatoprotective and renoprotective effects based on histopathological examination of tissues.
• Assessing molecular mechanisms of cholesterol reduction based on in silico virtual screening and molecular dynamic simulations.

Strengths

• The ethanolic extract's antioxidant activity is quantified with specific values: TPC of 61.83 ± 2.60 mg GAE/g, FRAP of 1712.9 ± 4.11 µg Fe/g, and DPPH inhibition of 79.47% ± 0.66%.
• The study includes a multi-dose experimental design (250, 500, and 750 mg/kg/day) and reports statistically significant (p < 0.05) outcomes for key biomarkers.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 55.9 KB DOCX file, suggesting limited scope and likely containing summary text rather than raw experimental data.

Provenance

Source

Khurram Afzal via figshare.

Collection Method

In vivo experiments on rats and in silico computational modelling.

Freshness

Last updated 2026-05-07 05:24:39; freshness should be verified.