Supplementary file 1_Isolated ventricular septal defect is not a risk factor for celiac di

493,382 children aged 0–10 years were followed for up to 10 years in a population-based retrospective cohort study using electronic health records. The research, authored by Ramon Cohen and shared on figshare, investigates the association between isolated ventricular septal defect and incident celiac disease. Results indicate VSD was not an independent risk factor, while type 1 diabetes mellitus and chromosomal anomalies showed strong associations.

Use Cases

• Validate the association between congenital heart defects and autoimmune diseases based on the study's cohort and methodology.
• Benchmark risk factors for celiac disease in pediatric populations based on the reported hazard ratios for type 1 diabetes and chromosomal anomalies.
• Design follow-up studies on pediatric electronic health record data based on the described multivariable Cox proportional hazards modeling approach.

Strengths

• Large cohort size of 493,382 children provides substantial statistical power.
• Study design includes up to 10 years of follow-up for incident disease identification.
• Multivariable models adjusted for multiple confounders including age, sex, and established comorbidities.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying dataset is unknown, which may limit suitability assessment.
• Data may reflect geographic or healthcare system bias inherent to the Clalit Health Services source.

Provenance

Source

Electronic health records from Clalit Health Services.

Collection Method

Population-based retrospective cohort study.

Time Range

Follow-up period of up to 10 years for children aged 0–10.

Freshness

Last updated 2026-03-18 06:57:45; freshness should be verified.