Isoviolanthin Effects on IL-1β-Stimulated Rat Chondrocytes

Supplementary file from a figshare study investigating the anti-inflammatory and cartilage-protective mechanisms of isoviolanthin in knee osteoarthritis. The research employed network pharmacology, molecular docking, and in vitro assays on rat chondrocytes, identifying key signaling pathways. The dataset likely contains results from Western blot, RT-qPCR, and immunofluorescence analyses.

Use Cases

• Validate anti-inflammatory targets based on network pharmacology results.
• Analyze gene expression changes in chondrocytes under IL-1β stimulation.
• Correlate molecular docking scores with observed biological effects.

Strengths

• Includes specific experimental results (e.g., 25 μM concentration, 141 overlapping targets).
• Focuses on defined biological pathways (PI3K-AKT, MAPK).
• Methodology is detailed (network pharmacology, molecular docking, in vitro assays).

Limitations

• Dataset size is 652.1 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred.
• Freshness should be verified; last updated 2026-05-22.

Provenance

Source

Jian-Li Yin via figshare.

Collection Method

Generated through laboratory experiments and computational analysis.