JHJD Formula: In Vitro SARS-CoV-2 Inhibition and Network Pharmacology Analysis

Zhan-Qun Yang authored a research document analyzing the JinHuangJieDu (JHJD) Traditional Chinese Medicine formula. The study evaluates JHJD's dual mechanism of action, including blocking SARS-CoV-2 RBD-ACE2 binding and attenuating virus-induced inflammation via HIF-1α modulation. The document was last updated on 2026-05-11.

Use Cases

• Validate drug candidates based on the described in vitro assays for SARS-CoV-2 spike RBD binding inhibition.
• Conduct network pharmacology analyses based on the described methodology identifying 375 ingredients and 338 target genes.
• Study HIF-1α-dependent inflammatory pathways in viral infections based on the validated mechanism of action.

Strengths

• The research describes a specific dual mechanism of action (RBD-ACE2 disruption and HIF-1α modulation).
• Network pharmacology analysis identified 375 ingredients and 338 target genes, providing a concrete scope for the study.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 3.7 MB file size suggests a small dataset, likely a supplementary document rather than a large structured dataset.

Provenance

Source

Zhan-Qun Yang via figshare

Collection Method

In vitro assays and computational network pharmacology analysis.

Freshness

Last updated 2026-05-11 05:28:57; freshness should be verified.