Konjac Extract Effects on Triple-Negative Breast Cancer Cell Migration and Invasion

8 triple-negative breast cancer tumor specimens were analyzed for OLFML2A expression and EMT markers. In vitro experiments used MDA-MB-231 cells treated with konjac petroleum ether extract, with migration and invasion assays performed in triplicate. The dataset, authored by Yian Chen and last updated in May 2026, is shared under a CC-BY-4.0 license.

Use Cases

• Analyze dose-response relationships based on gradient concentrations of konjac extract.
• Investigate correlations between OLFML2A expression and EMT marker levels based on qPCR and Western blot data.
• Model the inhibitory effects on cell migration and invasion based on wound healing and Transwell assay results.
• Validate gene knockdown phenotypes based on OLFML2A-knockout cell line data.

Strengths

• Includes data from 8 clinical tumor specimens.
• In vitro experiments were performed with n=3 replicates.
• Reports a specific IC50 value of 220 μg/mL for cell proliferation.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 2.3 MB size suggests a small dataset.

Provenance

Source

figshare

Collection Method

Experimental data from histopathology, qPCR, Western blot, and cell migration/invasion assays.

Freshness

Last updated 2026-05-15 05:27:47; freshness should be verified.