Longitudinal Profiling of γδ T Cell Dynamics in Human Lung Transplant Recipients

A longitudinal analysis tracking γδ T cell presence, chimerism, and phenotype in 13 lung transplant recipients for up to 3 years post-transplantation. The dataset, authored by Joshua H. Wang and shared under CC-BY-4.0, includes measurements from peripheral blood and bronchoalveolar lavage (BAL) samples.

Use Cases

• Modeling associations between donor-derived γδ T cell levels and acute cellular rejection incidence based on clinical outcome links.
• Analyzing phenotypic shifts from effector to tissue-resident memory states in recipient cells based on marker data (CD28, CD69, CD103, CD49a).
• Investigating correlations between recipient γδ T cell turnover rates and delayed infection onset or pulmonary function.
• Comparing systemic versus local (BAL) immune cell dynamics based on longitudinal sampling from blood and lung sites.

Strengths

• Longitudinal design with data collection spanning up to 3 years post-transplant.
• Includes paired samples from two distinct biological compartments: peripheral blood and bronchoalveolar lavage.
• Links specific immune cell phenotypes and kinetics to clinical outcomes like rejection and infection.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Dataset is relatively small (1.2 MB), suggesting limited sample size or feature scope.

Provenance

Source

figshare

Collection Method

Longitudinal analysis of samples from 13 lung transplant recipients.

Time Range

Up to 3 years post-transplantation.

Freshness

Last updated 2026-04-16 04:20:22; freshness should be verified.

Geography

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