Madhuca Longifolia Bark Extract and SN-38 Synergy Study in Colon Cancer Cells

Anna Barycka's research investigates the synergistic anticancer effects of combining a traditional plant extract with the chemotherapy drug SN-38. The study, last updated in May 2026, includes cytotoxicity data from human colorectal cancer cell lines HT-29 and HCT116 and normal epithelial cells FHC. Results indicate the bark extract sensitizes cancer cells to SN-38, potentially reducing required drug doses and side-effects.

Use Cases

• Analyzing cytotoxic effects of plant extracts based on SRB assay results described in the study
• Investigating drug synergy and combination therapy efficacy based on CompuSyn software analysis mentioned in the methods
• Studying apoptosis induction and reactive oxygen species production in cancer cells based on flow cytometry data
• Evaluating the selectivity of potential therapeutics based on comparative toxicity to cancer versus normal cells

Strengths

• The dataset is associated with a specific, peer-reviewed research methodology including SRB assays and flow cytometry.
• It provides pharmacological support for a traditional medicinal use of Madhuca longifolia, as stated in the conclusion.

Limitations

• The dataset is a single 22.9 KB DOCX file, indicating very limited scope and likely containing only supplementary textual information.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Anna Barycka via figshare

Collection Method

Laboratory research involving cytotoxicity assays, flow cytometry, and synergy analysis.

Freshness

Last updated 2026-05-12 05:26:35; freshness should be verified.