Supplementary file 1_Markers of neuroinflammation in the CSF of patients with difficult to

35 patients with atypical psychiatric presentations had serum and cerebrospinal fluid markers measured and compared against cohorts of non-inflammatory neurological disease controls (n=18), CNS viral infection patients (n=22), and autoimmune encephalitis patients (n=40). The dataset, authored by Jocelyn X. Jiang and last updated in May 2026, contains results suggesting a subset of patients may have an immune contribution to their condition.

Use Cases

• Identify potential CSF cytokine biomarkers for psychiatric disease based on measured markers like ITAC/CXCL11 and TARC/CCL17.
• Compare neuroinflammatory profiles between psychiatric, autoimmune, and infectious CNS conditions based on cohort data.
• Investigate the prevalence of serum autoantibodies, such as anti-nuclear and thyroid antibodies, in psychiatric populations.
• Assess the utility of extensive serological evaluation for revising diagnoses in atypical psychiatric cases.

Strengths

• Includes data from 115 total participants across four distinct clinical cohorts.
• Measures multiple marker types, including CSF cytokines, autoantibodies, and conventional CSF markers.
• Results revised the diagnoses of 6 patients (17% of the psychiatric cohort), demonstrating clinical relevance.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (18.6 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Clinical measurement of serum and CSF markers in patient cohorts.

Freshness

Last updated 2026-05-04 05:34:08; freshness should be verified.