Wuling Powder: Computational Pharmacology Analysis for Renal Ischemia-Reperfusion Injury

A 2.2 MB supplementary document published on figshare by Qian-Qian Wang on June 4, 2026, under a CC-BY-4.0 license. It details a computational systems pharmacology study combined with experimental validation to elucidate the mechanism of Wuling Powder in treating renal ischemia-reperfusion injury by regulating macrophage polarization.

Use Cases

• Identify potential drug targets for renal ischemia-reperfusion injury based on the described computational systems pharmacology pipeline
• Validate molecular docking predictions for herbal compounds based on the described methodology involving PLAUR, HSPA1A, and FOS
• Study macrophage polarization pathways in kidney injury using the mechanistic framework described
• Reproduce or extend the described multidimensional AI computational approach integrating network pharmacology and machine learning

Strengths

• The document is published under a permissive CC-BY-4.0 license, allowing for reuse and adaptation
• The study integrates multiple computational methods (network pharmacology, machine learning, molecular docking) with experimental validation
• Specific core targets (PLAUR, HSPA1A, FOS) and a key active compound (3,4-Dihydroxybenzaldehyde) are identified

Limitations

• The dataset is a single 2.2 MB DOCX file; the underlying computational data (e.g., gene expression matrices, docking scores) are not provided as separate, structured files
• Column-level documentation is absent; any tabular data within the document must be manually extracted and interpreted
• The row count and specific data formats for any embedded results are unknown

Provenance

Source

figshare

Collection Method

The data likely contains results from computational systems pharmacology analyses (network pharmacology, GEO database analysis, machine learning, molecular docking) and subsequent experimental validation.

Freshness

Last updated 2026-06-04 05:39:57