Supplementary file 1_Megestrol acetate in the management of cancer cachexia: a prospective

97 patients with cancer cachexia participated in a prospective, non-randomized study comparing a control group (n=33) to a group receiving megestrol acetate (n=64) over 2 months. The dataset, authored by Xiaoting Zhong and last updated in April 2026, contains results on primary endpoints like weight, BMI, and muscle mass, and secondary endpoints including inflammatory markers, immune parameters, fatigue, and quality of life. The study concluded that megestrol acetate significantly improved nutritional status and reduced cancer-related fatigue.

Use Cases

• Analyze the efficacy of megestrol acetate on weight and BMI changes based on the primary nutritional endpoints.
• Investigate the relationship between drug intervention and cancer-related fatigue scores across somatic, cognitive, and affective domains.
• Study the impact of megestrol acetate on inflammatory markers like IL-6 and TNF-α mentioned in the secondary endpoints.
• Compare changes in skeletal muscle mass preservation between treatment and control groups.
• Evaluate improvements in patient quality of life (QOL) associated with the pharmacological intervention.

Strengths

• The study design is clearly described as a prospective quasi-experimental study involving 97 patients.
• Specific primary and secondary endpoints are listed, including weight, BMI, muscle mass, fat mass, inflammatory markers, and patient-reported outcomes.
• The dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is a 12.0 KB DOCX file, suggesting it is a supplementary document rather than a structured data table, limiting direct computational analysis.
• Row count and column-level documentation are unknown; data structure and variable semantics must be inferred from the document text.
• The non-randomized study design may introduce selection bias not accounted for in the data.

Provenance

Source

figshare, authored by Xiaoting Zhong.

Collection Method

Data was likely collected as part of a prospective, non-randomized clinical study.

Time Range

The study intervention lasted for 2 months; specific years of data collection are not stated.

Freshness

Last updated 2026-04-21 04:22:24; freshness should be verified.