Browntop Millet Metabolite Data for Breast and Colorectal Cancer Cell Studies

Mahadevaswamy G. Kuruburu published a supplementary file on figshare in 2026 detailing metabolites from browntop millet. The study chemically characterized free and bound metabolites using UPLC-QTOF-MS and evaluated their anticancer efficacy in vitro and in vivo. Results showed metabolites contained bioactive phenolics and flavonoids with antioxidant activity and reduced cancer cell viability, with IC50 values ranging from 15.36 ± 0.86 to 67.44 ± 7.46 μg/mL.

Use Cases

• Identifying potential anticancer compounds based on UPLC-QTOF-MS metabolite characterization.
• Studying mechanisms of cell cycle arrest and apoptosis based on caspase-3 expression and DNA fragmentation data.
• Conducting in silico molecular docking studies based on metabolite binding affinity to COX-2 and mtALDH-2 proteins.
• Evaluating the in vivo antitumor efficacy of plant extracts based on EAC tumor growth suppression results.

Strengths

• Includes specific IC50 values for cancer cell viability reduction, ranging from 15.36 ± 0.86 to 67.44 ± 7.46 μg/mL.
• Describes a multi-method study combining in vitro, in vivo, and in silico analyses.
• Identifies specific bioactive metabolites like Formononetin-7-O-glucuronide and Apigenin-7-glucoside.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a 250.6 KB DOCX file, indicating a very small and likely document-based supplementary data scope.

Provenance

Source

figshare

Collection Method

Metabolites were extracted from browntop millet and characterized using UPLC-QTOF-MS; anticancer effects were tested in laboratory models.

Freshness

Last updated 2026-05-07 05:34:30; freshness should be verified.