Gut Microbiome Profiles of Egyptian Patients Across Liver Disease and HCV-HCC Stages

Shotgun metagenomic sequencing data from 46 Egyptian patients, categorized into five groups including healthy individuals and those with various liver disease stages. The dataset, created by Marwa Zahra and last updated on 2026-04-28, profiles microbial gene catalogs and taxonomic signatures. It examines associations between gut microbiome dysbiosis, hepatitis C virus infection, and hepatocellular carcinoma development.

Use Cases

• Identify microbial biomarkers for hepatocellular carcinoma based on taxonomic profiles and gene abundance.
• Compare gut microbiome recovery in treated HCV patients versus active disease states based on described microbial shifts.
• Investigate region-specific factors like antibiotic resistance genes and bile acid metabolism in Egyptian patients as described.
• Analyze associations between beneficial bacteria (e.g., Faecalibacterium) and pathogenic bacteria (e.g., Escherichia) across liver disease stages.

Strengths

• Includes data from 46 patients across five distinct clinical groups, enabling comparative analysis.
• Generated via shotgun metagenomic sequencing, which provides high-resolution taxonomic and functional profiling.
• Focuses on a specific, high-prevalence population (Egyptian patients with HCV and HCC), addressing a regionally relevant research gap.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale modeling.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is relatively small at 8.0 MB, which may constrain statistical power for some analyses.

Provenance

Source

figshare, author Marwa Zahra.

Collection Method

Shotgun metagenomic sequencing of patient samples.

Freshness

Last updated 2026-04-28 15:21:14; freshness should be verified.

Geography

Egypt