Methyl Eugenol Effects on Erythrocyte Aging: Human Cohort Data and In Silico Docking

A 5.5 MB supplementary document from a 2026 study investigating methyl eugenol's protective effects on aging human red blood cells. The research includes data from a human cohort of 81 donors aged 20-90 years, with analyses of glutathione and malondialdehyde levels, hemolysis assays, and in silico docking simulations. The dataset is authored by Jiasi Zhang and shared under a CC-BY-4.0 license.

Use Cases

• Modeling the relationship between oxidative stress markers and age based on glutathione and malondialdehyde data from the human cohort.
• Analyzing the structural basis of protein stabilization using the in silico docking results predicting interaction with residue ARG292.
• Investigating the concentration-dependent protective effects of methyl eugenol based on the reported optimal concentration of 2 µM.
• Studying correlations between intracellular calcium levels, calpain activity, and cell viability as described in the mechanistic results.

Strengths

• Includes data from a human cohort of 81 donors spanning ages 20 to 90 years.
• Reports specific quantitative results, such as an extension of projected glutathione half-life from 47.14 to 64.14 years.
• Mechanistic findings are supported by multiple methods, including sulfate uptake kinetics, Western blotting, and flow cytometry.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a DOCX document, which may require extraction and formatting for computational analysis.

Provenance

Source

figshare

Collection Method

Laboratory experiments on erythrocytes challenged with H2O2, combined with a human cohort study and in silico docking simulations.

Time Range

Study published in 2026; temporal coverage of human cohort data not specified.

Freshness

Last updated 2026-04-20 04:13:21; freshness should be verified.

Geography

Geography of the human donor cohort is not specified.