Molecular Mechanisms of Insulin Resistance in PCOS: A Scoping Review

Mikołaj Kisiała's scoping review, published on figshare in April 2026, systematically maps molecular disturbances in insulin signaling and carbohydrate metabolism in Polycystic Ovary Syndrome (PCOS). The review includes peer-reviewed original studies from PubMed, Embase, and Web of Science published between January 2018 and May 2025. It identifies recurrent mechanisms like IRS/PI3K/AKT signaling defects and GLUT4 regulation issues, primarily from studies on granulosa cells, ovarian tissue, and other metabolic systems.

Use Cases

• Literature synthesis for research planning based on the mapped molecular pathways like IRS/PI3K/AKT and MAPK signaling.
• Identifying gaps in human evidence for future study design based on the review's assessment of model systems.
• Analyzing tissue-specific mechanisms of insulin resistance based on evidence from granulosa cells, liver, and adipose tissue mentioned in the description.
• Exploring the role of androgen receptor-mediated metabolic reprogramming in PCOS based on the described mechanisms.

Strengths

• The review covers a defined time range of studies from January 2018 to May 2025.
• It systematically maps evidence from three major biomedical databases: PubMed, Embase, and Web of Science.
• The description details specific molecular pathways and tissue types investigated.

Limitations

• The dataset is a 13.7 KB DOCX file, indicating a very limited textual scope rather than a primary data collection.
• Row count and column-level documentation are absent; the content structure must be inferred after download.
• The description notes that evidence from human studies remains limited, with many mechanisms supported by rodent or cell models.

Provenance

Source

Mikołaj Kisiała via figshare

Collection Method

Systematic scoping review of peer-reviewed literature from PubMed, Embase, and Web of Science.

Time Range

Studies published between January 2018 and May 2025

Freshness

Last updated 2026-04 13 04:35:53

Geography

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