Mpox Coinfections and Clinical Manifestation in Africa: Systematic Review

A systematic review and meta-analysis registered in PROSPERO (CRD420251133960) and conducted through February 2025. The work includes 23 studies from across Africa, reporting pooled prevalence estimates for VZV and HIV coinfections among mpox cases. It was authored by Fabrice Zobel Lekeumo Cheuyem and published on figshare.

Use Cases

• Analyze coinfection prevalence patterns based on pooled prevalence estimates for VZV and HIV.
• Compare clinical symptom severity based on descriptions of variation by viral clades.
• Assess study heterogeneity based on reported subgroup analyses across WHO regions, countries, and settings.
• Evaluate diagnostic and management implications based on the discussion of coinfection burden and screening.

Strengths

• Includes 23 studies from across Africa, providing a continental perspective.
• Reports specific pooled prevalence figures: 8.73% for VZV-mpox coinfection and 4.29% for HIV-mpox coinfection.
• Follows PRISMA guidelines and is registered in a systematic review registry (PROSPERO).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The data file is a 635.0 KB DOCX document, which suggests the primary data may be embedded in textual tables or summaries rather than a structured tabular format.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of observational studies from multiple electronic databases and grey literature.

Time Range

Studies searched through 27 February 2025.

Freshness

Last updated 2026-05-07 04:37:23; freshness should be verified.

Geography

Africa