Multi-Omic Profiling of Proteasome Targets PSMA7/PSMB2 in Sepsis

A 2026 study by Dexiu Chen investigates the protective effects of the natural compound Handelin in sepsis. The dataset likely contains proteomic and transcriptomic data from zebrafish models and human sepsis patient cohorts, identifying PSMA7 and PSMB2 proteasome subunits as key targets. It is published on figshare under a CC-BY-4.0 license.

Use Cases

• Identifying drug-protein interactions based on DIA-CETSA profiling data
• Analyzing associations between proteasome subunit levels and clinical outcomes based on patient plasma proteomics
• Meta-analysis of gene expression patterns across sepsis cohorts based on transcriptomic datasets
• Molecular docking simulations based on predicted binding affinities for PSMA7/PSMB2

Strengths

• Includes data from multiple experimental models: zebrafish larvae, macrophages, and human patient cohorts
• Integrates proteomic (DIA-CETSA, 4D-DIA) and transcriptomic data from 10 independent cohorts
• File size is 1.2 MB, indicating a focused dataset

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The primary file format is DOCX, which may not be optimal for direct data analysis

Provenance

Source

figshare

Collection Method

Data-independent acquisition mass spectrometry (DIA-CETSA), 4D-DIA proteomics, and meta-analysis of public transcriptomic datasets.

Freshness

Last updated 2026-03-19 05:18:08