Supplementary file 1_Multi-omics integration identifies PGAP3 as a tumor-intrinsic factor

Weihao Liu's supplementary document from a 2026 figshare publication investigates tumor-intrinsic immune evasion in prostate cancer. The 2.5 MB DOCX file contains results from integrated transcriptome-wide Mendelian randomization, multi-cohort bulk and single-cell RNA sequencing, spatial transcriptomics, and immune profiling. The study identifies PGAP3 as a gene associated with metabolic reprogramming and reduced CD8+ T-cell infiltration.

Use Cases

• Prioritizing candidate risk genes for prostate cancer based on integrated multi-omics data mentioned in the description
• Analyzing correlations between gene expression (e.g., PGAP3) and immune cell infiltration (e.g., CD8+ T-cells) based on the study's findings
• Investigating metabolic pathway activity (e.g., biotin, aspartate/asparagine metabolism) in relation to tumor-intrinsic programs described in the results

Strengths

• Data is derived from integrated multi-omics methods, including Mendelian randomization, bulk and single-cell RNA sequencing, and spatial transcriptomics.
• The document is recent, last updated on 2026-03-18.
• Released under a permissive CC-BY-4.0 license.

Limitations

• The primary data format is a DOCX document, which likely contains textual results and figures rather than structured, machine-readable data tables.
• Column-level documentation and sample data are unavailable, making direct computational analysis difficult.
• The row count and specific data structure are unknown.

Provenance

Source

figshare, author Weihao Liu.

Collection Method

Integrated analysis from transcriptome-wide Mendelian randomization, multi-cohort RNA sequencing, spatial transcriptomics, and immune profiling, with in vitro validation.

Time Range

Publication date suggests data is current as of 2026.

Freshness

Last updated 2026-03-18 05:21:14.

Geography

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