Neural Stem Cell Transplantation Efficacy in Rodent TBI Models: A Meta-Analysis

18 preclinical studies published up to January 2024 were systematically reviewed and meta-analyzed to evaluate neural stem cell transplantation for traumatic brain injury. The analysis, conducted by Yifan Song, found significant improvements in neurological function and reductions in lesion volume in rodent models. The review is registered with PROSPERO under identifier CRD42024505552.

Use Cases

• Benchmarking the efficacy of NSC transplantation therapies based on reported neurological severity scores.
• Investigating sources of heterogeneity in preclinical outcomes based on reported transplantation dose and timing.
• Informing the design of future animal studies based on the quality assessment of 18 included studies.
• Validating meta-analytic methods for preclinical data based on the application of random-effects models and SMD calculations.

Strengths

• Includes a systematic review of 18 studies with clearly defined primary (mNSS) and secondary (lesion volume) outcomes.
• Provides quantitative meta-analysis results with standardized mean differences and 95% confidence intervals for both outcomes.
• Assesses study quality using the CAMARADES checklist, reporting a median score of 7.00.

Limitations

• The underlying data is a review document (23.4 MB DOCX); the raw experimental data from the 18 studies is not directly provided.
• Significant heterogeneity was reported for the lesion volume outcome, which the authors note may limit generalizability.
• Row count and column-level documentation for any aggregated data are unknown.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, and Web of Science.

Time Range

Studies published up to January 2024.

Freshness

Last updated 2026-05-21 05:42:40; freshness should be verified.