Supplementary File 1: Neuronal Exosomal miR-25-3p Attenuates M1 Microglial Activation

22.1 MB DOC file by Guangjun Hu, last updated June 3, 2026. The file contains supplementary data for a study investigating the role of neuron-derived exosomes in regulating microglial polarization and neuroinflammation. The research utilized a neuron–microglia transwell co-culture system and molecular assays.

Use Cases

• Validate molecular mechanisms of microglial polarization based on the described TLR4/NF-κB signaling pathway.
• Analyze gene expression patterns related to neuroinflammation mentioned in the study's background.
• Train models to predict neurotoxicity based on features of M1/M2 microglial activation states.
• Cross-reference exosomal miRNA targets with other datasets on perioperative neurocognitive disorders.

Strengths

• File size is 22.1 MB, indicating substantial supplementary content.
• License is CC-BY-4.0, allowing for open sharing and adaptation.
• Platform tags provide clear domain classification for discovery.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is contained in a DOC file, which may require conversion for computational analysis.

Provenance

Source

figshare

Collection Method

Likely contains supplementary data generated from a laboratory study using co-culture systems and molecular assays.

Freshness

Last updated 2026-06-03 16:17:56; freshness should be verified.