Systematic Review on Neuroplasticity in Substance Use Disorder, 2020–2025

57 studies published between 2020 and 2025 were integrated for this systematic review. The text document analyzes neuroplastic mechanisms in substance use disorder and brain recovery, authored by Roberto Estrada-Medina and last updated in March 2026. The review identifies alterations in synaptic density, BDNF signaling, and neuroimaging changes, along with four core therapeutic domains.

Use Cases

• Extract key neurobiological mechanisms for literature reviews based on the analysis of synaptic and epigenetic changes.
• Identify potential therapeutic targets for machine learning in drug discovery based on the described neuroplastic restoration domains.
• Train NLP models to classify addiction research literature based on the structured review of 57 studies.
• Support meta-analysis research on neuromodulation efficacy based on the compiled evidence from rTMS, tDCS, and DBS studies.

Strengths

• Follows PRISMA 2020 guidelines for systematic review methodology.
• Integrates findings from 57 specific studies published within a defined 2020–2025 timeframe.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is a 286.7 KB DOCX file, indicating a limited textual scope rather than raw experimental data.
• Row count and column-level documentation are absent; data structure must be inferred from the document.
• Methodological heterogeneity and limited clinical generalizability are noted as gaps in the source material.

Provenance

Source

Roberto Estrada-Medina via figshare.

Collection Method

Systematic literature review conducted per PRISMA 2020 guidelines.

Time Range

Covers studies published between 2020 and 2025.

Freshness

Last updated 2026-03-18 07:41:05.

Geography

null