NHHR and Disease Risk in NAFLD Patients from a Clinical Cohort and NHANES

A retrospective cohort study from 2018–2025 involving 13,741 NAFLD patients from a Chinese hospital, with validation using NHANES data from 1999–2018. The dataset was created by Yanqi Kou and analyzes the association between the Non-HDL-to-HDL Cholesterol Ratio (NHHR) and incident type 2 diabetes and coronary heart disease. It was last updated on 2026-05-19.

Use Cases

• Predicting incident type 2 diabetes risk based on NHHR levels in NAFLD patients.
• Investigating nonlinear dose–response relationships between lipid ratios and metabolic disease outcomes.
• Conducting mediation analysis to understand the role of fasting glucose in the NHHR–T2DM association.
• Assessing the heterogeneity of cardiovascular risk prediction using NHHR across different patient cohorts.

Strengths

• Includes data from 13,741 patients in a primary clinical cohort, providing a substantial sample size.
• Findings are externally validated using the NHANES cohort comprising 5,789 individuals.
• Analysis includes multivariate logistic regression, restricted cubic splines, and mediation analysis as described.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary data file is unknown, which may limit suitability assessment.
• The dataset is small (128.1 KB), indicating limited scope, likely containing summary or supplementary results rather than raw patient records.

Provenance

Source

Affiliated Hospital of Guangdong Medical University (primary cohort) and NHANES (validation cohort).

Collection Method

Retrospective cohort study with multivariate logistic regression analysis.

Time Range

Primary cohort: 2018–2025; Validation cohort: 1999–2018.

Freshness

Last updated 2026-05-19 05:29:14; freshness should be verified.

Geography

Primary cohort: China; Validation cohort: United States (NHANES).